Can the blood transfusion device be used for infusion?

Can the blood transfusion device be used for infusion?
The blood transfusion device is a special infusion device set to adapt to blood and its products, which is not suitable for infusion.
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1. Type of infusion set and filter aperture
At present, there are basically three kinds of infusion sets in clinical use: one is a common PVC infusion set with a filter aperture of 15um; One is a precision infusion set containing PVC, with a filtering aperture of 3um, 5um, or even smaller; The other is TPE infusion set without PVC plasticizer, with a filter aperture of 15um, which can prevent the adsorption of emulsions and oils, such as nitroglycerin, butylphenyl peptide injection and some chemotherapy drugs.
2. Material and filter aperture of blood transfusion device
At present, 90% of the pipes and funnels of domestic infusion sets are made of PVC, and the filter aperture is 170 um~260 um. If the aperture is too small, it is easy to be blocked by the platelet leukocyte aggregates in blood cells, affecting the effective filtering area.
3. Characteristics of concentrated red blood cells
The diameter of a single red blood cell is 6-9 microns. However, since most plasma, platelets and white blood cells are removed from concentrated red blood cells, the concentration of red blood cells increases, and many red blood cells are often bonded together, so the viscosity of concentrated red blood cells is greater than that of whole blood, and the smoothness is only 60% of that of whole blood.
4. Requirements for infusion set during infusion of various drugs
(1) Infusion of Chinese patent medicine: Due to impurities due to the lack of purification process or insufficient dissolution of powder injection during the preparation of Chinese patent medicine preparation, the number of particles increases, so the precise infusion device with drug filtering device should be selected for infusion, with the filtering aperture of 2.2~5 μ m. The drug adsorptivity<28.6% is good. disposable infusion set 
disposable infusion set 
(2) Nutrient: It is mentioned in the 2016 INS filter clause in the United States that 0.2 micron filter is used to filter fat free parenteral nutrient solution, 1.2 micron filter is used to filter fat containing emulsion, and the filter is replaced every 24 hours.
5. Infusion particulate pollution and filter
It is mentioned in the 2016 US INS filter clause that the constantly updated research evidence suggests that particulate matter (such as rubber, glass, latex) has an impact on capillary endothelial cells, and micro bubbles in liquid may cause cerebral and pulmonary ischemia; The use of filters with particle trapping and air elimination functions can prevent potential damage from air/particles (such as right to left shunt heart malformation).
Infusion particles are non metabolic particles existing in the liquid. Most of them are 1-15 microns in diameter, and a few can be 50-300 microns. Larger particles can cause local vascular blockage or insufficient blood supply, tissue hypoxia, promote phlebitis and edema, granuloma, and even promote the formation of tumors. Insoluble particles can also cause allergic reactions and pyrogenic reactions. disposable infusion set 
6. Adsorption of PVC material on drugs
PVC material has strong adsorption to some alcohol soluble and fat soluble drugs, which makes the prescription inaccurate and affects the therapeutic effect. These drugs mainly include paclitaxel, nitroglycerin injection, isosorbide mononitrate injection, nimodipine, clonazepam, diazepam, chlorpromazine, urokinase, insulin, fat emulsion, Brucea javanica oil, ligustrazine, amiodarone, fentanyl, tinidazole, zedoary turmeric oil, etc. disposable infusion set 
summary
To sum up, in view of the PVC material of the blood transfusion device and the large aperture of the filter screen, it shows that the blood transfusion device is a special infusion device set to adapt to blood and its products, and it is not suitable for infusion.